阿魏酸钠(SF)为中药当归抗血小板有效成份,有报道它抑制血小板前列腺素代谢及磷酸二酯酶活性,升高血小板cAMP含量。我们给家兔注射SF后,有效对抗花生四烯酸(AA)肺栓塞肺动脉压升高,并发现血浆cGMP明显增加。为了解血浆与血小板cGMP变化是否一致及SF抑制聚集与血小板 Sodium ferulate (SF) is an active ingredient of Chinese angelica antiplatelet, and it is reported that it inhibits platelet prostaglandin metabolism and phosphodiesterase activity, and increases platelet cAMP content. After injecting SF into rabbits, we effectively antagonized the increase of pulmonary arterial pressure of arachidonic acid (AA) pulmonary embolism and found that plasma cGMP increased significantly. To understand whether plasma and platelet cGMP changes are consistent and SF inhibit aggregation with platelets