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目的:研究玉叶金花苷酸甲酯对LPS诱导RAW264.7巨噬细胞NO分泌量的影响。方法:采用LPS诱导RAW264.7细胞建立细胞炎症反应模型,利用NO试剂盒检测NO分泌量。结果:玉叶金花苷酸甲酯能够显著减少LPS诱导的RAW264.7细胞NO的产生和释放,与对照组比较,差异有统计学意义(P<0.01)。结论:玉叶金花苷酸甲酯可能通过减少NO的释放量而发挥抗炎作用。
Objective: To study the effects of Grifola frondosa on the NO production of LPS-induced RAW264.7 macrophages. Methods: RAW264.7 cells were induced by LPS to establish a model of inflammatory reaction and NO secretion was measured by NO kit. Results: JGG significantly reduced NO production and release in LPS-induced RAW264.7 cells, compared with the control group, the difference was statistically significant (P <0.01). Conclusion: Grifola frondosa methyl ester may exert anti-inflammatory effects by reducing NO release.