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炎性细胞被吸聚进入中枢神经系统 ( CNS)是包括多发性硬化 ( MS)在内的炎性脱髓鞘疾病的基本病理过程。通过实验性自身免疫性脑脊髓炎 ( EAE)研究表明 ,发生免疫介导的炎性反应时 ,被称为“趋化因子”的趋化性白细胞因子在调节淋巴细胞进入 CNS组织的过程中发挥重要而独特的作用。
Inflammatory cells are sucked into the central nervous system (CNS) as the basic pathological process of inflammatory demyelinating diseases including multiple sclerosis (MS). Studies by experimental autoimmune encephalomyelitis (EAE) have shown that chemotactic leukocytes known as “chemokines” play a role in the regulation of lymphocyte entry into the CNS tissue upon an immune-mediated inflammatory reaction Important and unique effect.