目的:探讨左乙拉西坦对女性精神发育迟滞癫痫患者精神状态?心理情绪及不良反应的影响?方法:选取52例女性精神发育迟滞癫痫的病患(收治于2020年1月~2021年1月)作为研究对象，均对此次研究的患者采取左乙拉西坦药物治疗的方式，对患者的精神状态及心理情绪进行观察，并对患者的不良反应进行记录?结果:治疗后患者MOCA评分提高，BPRS评分降低，与治疗前比较差异有统计学意义(P<0.05);治疗后患者SAS?SDS评分均降低，与治疗前比较差异有统计学意义(P<0.05);此次研究的52例患者中，实施治疗后显效的“,”Objective: To investigate the effects of levetiracetam on mental state， psychological emotion and adverse reactions in female pa- tients with mental retardation epilepsy. Methods: a total of 52 female patients with mental retardation epilepsy(admitted from January 2020 to Jan- uary 2021) were selected as the study subjects. The patients were treated with levetiracetam， and their mental state and psychological mood were observed， and the adverse reactions of the patients were recorded. Results: MOCA score was improved and BPRS score was decreased after treat- ment， and the difference was statistically significant(P<0.05).SAS and SDS scores of patients decreased after treatment， and the differences were statistically significant(P<0.05 ).Among the 52 patients in this study， 38 patients showed significant effect after the implementation of treatment， 12 were improved and 2 were ineffective， with a total effective rate of 96. 1%.Among the 52 patients in this study， gait instability oc- curred in 2 patients， fatigue and lethargy occurred in 1 patient， and the incidence of adverse reactions was 7.7%.The occurrence of adverse reac- tions is relatively mild， patients can carry out their own remission. Conclusion: Levetiracetam has a significant therapeutic effect on female mental retardationepilepsypatients，whichnotonlyimprovesthepatient＇smentalstateandpsychologicalmood，butalsohasfeweradversereactions，so the treatment is more suitable for clinical treatment.