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目的:评价头孢他啶和头孢噻肟治疗新生儿败血症的临床效果。方法:以头孢呋辛作对照,回顾性观察头孢他啶和头孢噻肟在新生儿败血症治疗中的疗效及安全性。结果:头孢他啶组、头孢噻肟组的有效率分别为91.30％、94.12％,与对照组头孢呋辛组(89.12％)比较均无显著差异(P>0.05);不良反应发生率也无显著差异(P>0.05);但头孢噻肟钠组与头孢他啶组住院天数均比对照组短(P<0.05)。结论:头孢他啶与头孢噻肟可作为新生儿败血症治疗的首选药物。
Objective: To evaluate the clinical efficacy of ceftazidime and cefotaxime in the treatment of neonatal sepsis. Methods: To cefuroxime as control, retrospective observation of ceftazidime and cefotaxime in the treatment of neonatal sepsis efficacy and safety. Results: The effective rates of ceftazidime group and cefotaxime group were 91.30% and 94.12%, respectively, which were not significantly different from those of cefuroxime group (89.12%) (P> 0.05). The incidence of adverse reactions was also not significantly different (P> 0.05). However, the length of stay in cefotaxime sodium group and ceftazidime group was shorter than that in control group (P <0.05). Conclusion: Ceftazidime and cefotaxime can be used as the drug of choice for the treatment of neonatal sepsis.