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目的研究猫脑皮质脊髓束早期Wallerian变性(WD)在3D-TSE-T2加权像上信号强度动态变化过程。方法对8只家猫实施单侧皮质脊髓束(CST)起源脑区切除术,选取连续的8个时间点,即建模前、建模后2天、4天、6天、8天、10天、20天、30天进行MRT2加权扫描。通过放置感兴趣区(ROI),分别获得患侧与健侧皮质脊髓束走行区的T2信号强度值(T2s),计算患侧与健侧T2s比值即相对T2信号强度(rT2s)。结果手术后至第4天,T2WI未见明显异常信号,rT2s值相对稳定;第6～10天,T2WI见患侧开始出现异常低信号,rT2s值急剧下降;第10～30天内,患侧仍表现为T2WI明显低信号,rT2s值保持相对稳定,但30天时rT2s值有升高趋势。结论 T2WI能比较敏感地监测早期WD。
Objective To investigate the dynamic changes of signal intensity on the 3D-TSE-T2 weighted image in early Wallerian degeneration (WD) of the cortical spinal cord of cats. Methods Eight cats were involved in the brain excision of unilateral corticospinal tract (CST). Eight consecutive time points were selected, that is, before modeling, 2 days, 4 days, 6 days, 8 days, 10 days after modeling Day, 20 days, 30 days MRT2 weighted scan. The T2 signal intensity (T2s) of the ipsilateral and contralateral cortical spinal cord tracts were obtained respectively by placing ROIs, and the relative T2 signal intensity (rT2s) was calculated between affected and contralateral T2s. Results There was no obvious abnormal signal on T2WI and rT2s was relatively stable after operation. On the 6th to 10th day, abnormal low signal began to appear on T2WI and the value of rT2s dropped sharply. On the 10th to 30th day, The results showed that T2WI significantly low signal, rT2s values remained relatively stable, but 30 days rT2s values have increased. Conclusion T2WI can monitor early WD more sensitively.