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目的 了解庆阳市神经管缺陷的发生现状及变化趋势,为下一步防治工作提供依据.方法 采用以助产机构为基础的监测方法,收集庆阳市2012-2016年所有助产机构上报的出生缺陷资料,并应用SPSS19.0进行统计分析.结果 庆阳市2012-2016年神经管缺陷总发生率为18.09/万,且发生呈下降趋势.其中脊柱裂、无脑畸形和脑膨出的发生率分别为7.73/万、7.61/万和2.76/万.男女性别比为1∶1.68.结论 庆阳市神经管缺陷总发生率高于全国平均水平.女性明显多于男性.对脊柱裂和无脑畸形应加强研究,重点干预.“,”Objective:To understand the occurrence and trend of neural tube defects in Qingyang,and provide evidence for further prevention and treatment.Methods:Adopting the monitoring method based on midwifery institution,the data of birth defects reported by all midwifery institutions in Qingyang during the 2012-2016 years were collected and analyzed by SPSS19.0.Results:The total incidence of neural tube defects in Qingyang in 2012-2016 years was 18.09/10000,and it showed a downward trend.Among them,the incidence of spinal bifida,anencephalia and encephalocele were 7.73/10000,7.61/10000and,2.76/10000.The sex ratio of male and female is 1 ∶ 1.68.Conclusion:The total incidence of neural tube defects in Qingyang is higher than the national average.Women are significantly more than men.We should strengthen the study of spina bifida and anencephalia,and focus on intervention.