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目的探讨和研究激素替代治疗联合降压药物对围绝经期原发性高血压女性血压及内皮功能的影响。方法收集围绝经期原发性高血压患者60例,随机分为观察组与对照组,每组30例。对照组患者给予降压药物治疗,观察组在对照组的基础上加用小剂量激素进行治疗,两组患者在治疗前后均检测血压、前列环素、卵泡刺激素和雌激素水平,并对治疗后的相关指标数据进行对比和分析。结果观察组与对照组治疗后前列环素、卵泡刺激素和雌激素水平比较差异均有统计学意义(P<0.05);收缩压与舒张压比较差异无统计学意义(P>0.05)。结论治疗围绝经期原发性高血压女性时,激素替代治疗联合降压药物能够有效改善患者血管内皮细胞功能和围绝经期症状,无不良作用,值得推广应用。
Objective To investigate and study the effects of hormone replacement therapy combined with antihypertensive drugs on blood pressure and endothelial function in women with essential hypertension in perimenopausal period. Methods Sixty patients with peri-menopausal essential hypertension were collected and randomly divided into observation group and control group with 30 cases in each group. Patients in the control group were treated with antihypertensive drugs. The observation group was treated with low-dose hormone on the basis of the control group. Blood pressure, prostacyclin, follicle-stimulating hormone and estrogen levels were measured in both groups before and after treatment. After the relevant index data for comparison and analysis. Results There were significant differences in the levels of prostacyclin, follicle stimulating hormone and estrogen between the observation group and the control group after treatment (P <0.05). There was no significant difference in systolic and diastolic blood pressure between the observation group and the control group (P> 0.05). Conclusions Hormone replacement therapy combined with antihypertensive drugs can effectively improve the function of vascular endothelial cells and perimenopausal symptoms in patients with essential hypertension during perimenopausal period without any adverse effect and is worth popularizing and applying.