【摘 要】
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Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world.It is caused by a novel coronavirus,severe acute respirator
【机 构】
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Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southe
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Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world.It is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).The spike (S) protein of SARS-CoV-2,which plays a key role in the receptor recognition and cell membrane fusion process,is composed of two subunits,S1 and S2.The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2,while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain.In this review,we highlight recent research advance in the structure,function and development of antivirus drugs targeting the S protein.
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