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目的 探讨转化生长因子 β1(transforminggrowthfactor β1,TGF β1)在诱导大鼠心肌细胞肥大中的作用。方法 培养新生大鼠的心肌细胞 ,检测 [3 H] Leu的掺入量和胚胎抗原心房利钠因子 (atrialnatriuret icfactor,ANF)的表达。结果 不同浓度的转化生长因子 β1均能明显增加心肌细胞 [3 H] Leu的掺入量和ANF的表达。结论 转化生长因子 β1能诱导大鼠的心肌细胞肥大
Objective To investigate the role of transforming growth factor β1 (TGF β1) in inducing cardiomyocyte hypertrophy in rats. Methods Cardiomyocytes of newborn rats were cultured and the [3H] Leu incorporation and the expression of atrial natriuretic factor (ANF) were detected. Results Different concentrations of TGF - β1 could significantly increase [3H] Leu incorporation and ANF expression in cardiomyocytes. Conclusion Transforming growth factor β1 can induce cardiomyocyte hypertrophy in rats