目的　探讨支气管哮喘患者嗜酸性粒细胞凋亡情况和激素治疗对其影响。方法　对 30例急性发作期、激素治疗后缓解期支气管哮喘患者和 30例健康人 ,经纤维支气管镜取支气管肺泡灌洗液用免疫细胞化学方法进行嗜酸性粒细胞凋亡的研究。结果　支气管哮喘患者急性发作期 ,激素治疗后的缓解期和健康人组嗜酸性粒细胞凋亡百分比分别是 (3.5 0± 1.5 9) %、(5 .5 3± 2 .2 2 ) %和 (6 .90± 3.2 7) %。 3组间差异显著 (P <0 .0 0 1)。结论　支气管哮喘患者存在着嗜酸性粒细胞凋亡异常 ,经激素治疗后可改善嗜酸性粒细胞凋亡。嗜酸性粒细胞凋亡是支气管哮喘发病机制中的主要环节之一 Objective To investigate the eosinophil apoptosis in patients with bronchial asthma and its effect on hormone therapy. Methods The eosinophil apoptosis was studied by immunocytochemistry in bronchial bronchoalveolar lavage fluid in 30 patients with acute exacerbation of asthma and 30 healthy individuals after remission. Results The percentages of eosinophils apoptosis in acute phase of asthma were (3.5 ± 1.59)%, (5.3 ± 2.2.2)% and (± 6 .90 ± 3.2 7)%. The differences among the three groups were significant (P <0. 001). Conclusion There is abnormal eosinophil apoptosis in patients with bronchial asthma, which can improve the eosinophil apoptosis after steroid treatment. Eosinophil apoptosis is one of the main links in the pathogenesis of bronchial asthma