血栓性血小板减少性紫瘢(TTP)是一种罕见的血液学综合征,它的临床特点是微血管内溶血性贫血、血小板减少、发热、神经症状和肾功能不全。目前,对其病因了解很少,对各种治疗方法的优劣众说纷云,很难评价。本文对10例 TTP 患者(男4例,女6例)作了回顾性调查,患者全部具有典型临床特点,其中9例有确切的组织学发现为佐证。4例患者未作脾切除术,全部在入院后2小时至4天内死亡;6例作脾切除者存活半年至18年。1例在每日强的松40mg 治疗4周无效后,作脾切除,病情随即缓解。另1例因长 Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic syndrome characterized by microvascular hemolysis, thrombocytopenia, fever, neurological symptoms, and renal insufficiency. At present, little is known about its etiology, and it is difficult to evaluate the advantages and disadvantages of various treatment methods. In this paper, 10 cases of TTP patients (4 males and 6 females) were retrospectively surveyed, all patients with typical clinical features, of which 9 cases have confirmed the exact histological findings. No splenectomy was performed in 4 patients, all of which died within 2 hours to 4 days after admission. 6 patients who underwent splenectomy survived for 6 months to 18 years. One case of prednisone 40mg daily treatment for 4 weeks after the invalid, for splenectomy, the disease was relieved. Another case of long