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Objective: The paper aimed to study the relationship between the expressions of immunoglobulin G (IgG) subclassestoward human papillomavirus 16-like particles (HPV16VLPs) in the serum of patients and different grades of cervicallesions. Methods: The expressions of IgG subclasses in 32 cases of human papillomavirus (HPV) infection, 30 cervicalintraepithelial neoplasia (CIN I), 43 CIN II-III, and 24 hysteromyoma and chronic cervicitis were examined by ELISA. Results:The absorbance values of HPV16VLPs-IgG, IgG1 increased with the grade of CIN (P 1) from control group was 100%, 87.50% for HPV infection group, 75% for CIN I group, compared with that fromCIN II-III patients (9.52%) (P 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.