近年来，雾化吸入治疗越来越普遍地用于机械通气患者，而人工气道的建立改变了气溶胶输送环境和方式，目前已有《机械通气时雾化吸入专家共识》指导临床，但是由于雾化吸入步骤繁琐，药品繁多，很多呼吸机不支持雾化吸入治疗，同时雾化吸入的疗效受众多因素影响，如呼吸机模式选择、参数设置、加温湿化、人工鼻和过滤器的使用等，往往导致临床治疗效果不佳，甚至对呼吸机造成损坏。为规范机械通气雾化吸入技术的临床应用，避免操作中可能出现的诸多问题，河南省医学会重症医学分会呼吸治疗学组委员共同讨论，得出本临床路径，为机械通气雾化吸入的实际操作和给药提供临床参考。“,”In recent years, atomization inhalation therapy has been more and more commonly used in patients with mechanical ventilation. However, the establishment of artificial airway has changed the environment and mode of aerosol delivery. Currently, n Expert consensus on atomization inhalation during mechanical ventilation has been established to guide clinical practice. However, many ventilators do not support the treatment of aerosol inhalation due to the tedious procedures and numerous drugs. At the same time, the therapeutic effect of atomization inhalation is affected by many factors, such as ventilator mode selection, parameter setting, heating and humidification, using of artificial nose and filter, etc., which often results in poor clinical effects or even damage to the ventilator. In order to standardize the clinical application of mechanical ventilation atomization inhalation technology and avoid many possible problems in operation, the committee members of Respiratory Therapy Group of Severe Medicine Branch of Henan Medical Association discussed and concluded this clinical path, so as to provide clinical reference for the actual operation and drug administration of mechanical ventilation atomization.n