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目的观察黏附分子整和素α6β4在膀胱癌中的表达及其与膀胱癌分化,侵袭转移的关系。方法应用免疫组织化学方法对83例膀胱癌石蜡包埋标本进行整和素α6β4半定量检测,其中≥60%细胞呈强阳性反应(+++),30%～60%呈弱、中等强度阳性反应(++)。结果有59例膀胱癌组织整和素α6β4呈阳性或不同程度表达增强(x~2=53.78,P<0.05),高分化癌的整和素α6β4阳性率明显低于低分化癌(x~2=17,P<0.05)。整和素α6β4阳性率在膀胱癌伴淋巴结转移组高于淋巴结阴性组(x~2=12.1,P<0.05)。结论整和素α6β4表达与肿瘤细胞的分化程度呈负相关、与淋巴结转移呈正相关,整和素可作为判断膀胱癌恶性程度及患者预后的生物学指标。
Objective To investigate the expression of integrin α6β4 in bladder cancer and its relationship with the differentiation, invasion and metastasis of bladder cancer. Methods Immunohistochemistry was used to detect the expression of integrin α6β4 in 83 specimens of bladder cancer. 60% of them showed strong positive reaction (+++), while 30% -60% of them were weak and moderately positive Reaction (++). Results The positive rate of integrin α6β4 in 59 cases of bladder cancer was significantly higher than that in poorly differentiated carcinoma (x ~ 2 = 53.78, P <0.05). The positive rate of integrin α6β4 in well differentiated carcinoma was significantly lower than that in poorly differentiated carcinoma = 17, P <0.05). The positive rate of integrin α6β4 in bladder cancer with lymph node metastasis was higher than that in lymph node negative (x ~ 2 = 12.1, P <0.05). Conclusion The expression of integrin α6β4 is negatively correlated with the degree of differentiation of tumor cells and positively correlated with lymph node metastasis. Integrin can be used as a biological index to judge the malignant degree of bladder cancer and the prognosis of patients.