论文部分内容阅读
脂联素是脂肪细胞分泌的一种生物活性分子,是一种蛋白质激素,具有抗炎、抗动脉粥样硬化的作用。炎症、氧化应激与内皮功能紊乱一起加速了终末期肾脏病患者动脉粥样硬化的发生,尽管终末期肾脏病血液透析、腹膜透析患者和中度肾功能不全患者高发胰岛素抵抗和心血管疾病,但血脂联素水平增加。低脂联素与心血管疾病预后差有关,血脂联素可能减轻血液透析患者氧化应激。本文对脂联素与慢性肾功能不全的关系作一综述。
Adiponectin is a bioactive molecule secreted by adipocytes and is a protein hormone with anti-inflammatory and anti-atherosclerotic effects. Inflammation, oxidative stress and endothelial dysfunction accelerate atherosclerosis in patients with end-stage renal disease. Although end-stage renal disease patients undergoing hemodialysis, peritoneal dialysis and moderate renal insufficiency develop insulin resistance and cardiovascular disease, However, blood adiponectin levels increased. Low adiponectin is associated with poor prognosis of cardiovascular disease, and blood adiponectin may reduce oxidative stress in hemodialysis patients. This article reviews the relationship between adiponectin and chronic renal insufficiency.