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目的:研究参芪柔脉合剂对颈动脉粥样硬化试验兔炎性因子的影响。方法:将新西兰大耳白兔60只分为空白组9只,模型组51只,对模型组行颈动脉球囊内膜损伤术联合高脂饲料喂养制备动脉粥样硬化兔模型,将造模成功的50只试验兔采用随机数字表法分为模型组、西药组、中药高剂量组、中药中剂量组、中药低剂量组,各10只。分组后开始分别灌胃给药或给水,于给药前后取血测炎性因子指标的含量,于本次给药后取颈动脉观察其形态学变化。结果:给药前,与空白组比较,模型组于给药前后hs-CRP、TNF-a、IL-10值变化差异有统计学意义(P<0.01);给药前后组内比较,西药组、中药高剂量组和中药中剂量组的hs-CRP、TNF-a值均降低,IL-10值升高(P<0.01或P<0.05);给药后西药组、中药高剂量组、中药中剂量组和中药低剂量组与模型组比较hs-CRP、TNF-a值均降低,IL-10值升高(P<0.01或P<0.05),在升高IL-10值上中药高剂量组和中药中剂量组优于西药组(P<0.01或P<0.05)。肉眼观察示各给药组试验兔颈动脉病变程度均有变化。结论:参芪柔脉合剂治疗可调节CAS兔炎性因子水平。
Objective: To study the effect of Shenqi Rouma mixture on inflammatory factors in rabbits with carotid atherosclerosis. Methods: 60 New Zealand white rabbits were divided into blank group (n = 9) and model group (n = 51). Rabbits model of atherosclerosis were prepared by carotid balloon intimal injury and high fat diet. Fifty successful experimental rabbits were randomly divided into model group, western medicine group, high-dose Chinese medicine group, medium-dose Chinese medicine group and low-dose Chinese medicine group. After grouping, they were given gavage or water respectively, and blood samples were taken before and after administration to measure the content of inflammatory factors. The carotid arteries were taken after the administration to observe the morphological changes. Results: Compared with the blank group, the changes of hs-CRP, TNF-a and IL-10 in the model group before and after administration were statistically significant (P <0.01) (P <0.01 or P <0.05); Western medicine group, traditional Chinese medicine high-dose group, traditional Chinese medicine group Compared with model group, hs-CRP and TNF-a decreased and IL-10 increased (P <0.01 or P <0.05) in middle-dose group and low- Group and traditional Chinese medicine group was better than Western medicine group (P <0.01 or P <0.05). Macroscopic observation showed that the experimental rabbits in each experimental group had varying degrees of carotid artery lesions. Conclusion: Shenqi soft veins mixture can regulate inflammatory cytokines in CAS rabbits.