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家兔的冠状动脉主支属壁动脉,故不易发生动脉粥样硬化(以下简称AS)。常用的大剂量胆固醇短期内诱发的家兔冠状动脉粥样硬化主要发生在中、小支,且其病变性质与人类冠状动脉AS有很大的差别。本试验以低剂量胆固醇喂饲家兔3年,试图诱发与人类相似的冠状动脉主支病变,并观察其形态发生发展的过程。
Rabbit coronary artery wall artery, it is not prone to atherosclerosis (hereinafter referred to as AS). Commonly used high-dose cholesterol induced short-term coronary atherosclerosis in rabbits mainly occurs in the small branches, and the nature of the lesions and human coronary artery AS has a great difference. In this study, rabbits were fed with low-dose cholesterol for 3 years to try to induce the main branch of coronary artery disease similar to human, and to observe the morphogenesis of the process.