Psoriasis is a chronic,immune mediated,systemic inflammatory skin disease with a reported prevalence of 0.6％-4.8％ in the general population.Bipolar disorder (BP) is a severe episodic psychiatric disorder that ranks as the fourth leading cause of disability.Recent evidence suggests that genetic and immunological factors play a significant role in the development of both disorders.Studies have also shown a higher association of psychiatric disorders among patients with psoriasis.Moreover,several autoimmune comorbidities have been reported in association with BP.Here,we describe a young woman with BP who developed psoriasis after 1 year of developing BP and showed exacerbations in psoriasis lesions with each manic episode.We also highlight the safe and efficacious use of apremilast for psoriatic lesions in the woman.