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目的探讨血浆同型半胱氨酸(hemocysteine,Hcy)水平与颈动脉粥样硬化及脑梗死的关系。方法 86例动脉粥样硬化性脑梗死患者为脑梗死组,选择同期健康体检者78例为对照组。进行颈动脉多普勒超声检测颈动脉内膜-中层厚度(IMT)。根据血管动脉硬化程度分组,比较不同程度颈动脉粥样硬化患者Hcy水平,对部分高Hcy水平患者给予维生素B12、叶酸治疗1个月后,观察Hcy水平的变化。结果脑梗死组患者血浆Hcy、IMT均显著高于对照组,差异有统计学意义(P<0.05);患者的血浆Hcy水平与IMT呈正相关(r=0.689,P<0.05)。结论 Hcy水平升高与脑梗死的发生及颈动脉硬化程度有一定关系。
Objective To investigate the relationship between plasma homocysteine (Hcy) level and carotid atherosclerosis and cerebral infarction. Methods A total of 86 patients with atherosclerotic cerebral infarction were selected as cerebral infarction group and 78 healthy subjects were selected as the control group. Carotid artery Doppler ultrasound was used to detect carotid intima-media thickness (IMT). Hcy levels in patients with carotid atherosclerosis were compared according to the degree of vascular atherosclerosis. Vitamin B12 was given to some patients with high Hcy levels, and folic acid treatment for 1 month to observe the change of Hcy levels. Results Plasma Hcy and IMT in patients with cerebral infarction were significantly higher than those in control group (P <0.05). There was a positive correlation between Hcy and IMT in patients with cerebral infarction (r = 0.689, P <0.05). Conclusion Hcy levels and cerebral infarction and carotid atherosclerosis have a certain relationship.