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目的探讨测定mAST活力在肝病类型诊断中的临床价值.方法用免疫押制法测定310例肝病患者及75例健康体检者(对照组)的血清mAST,同时测定AST,并测定mAST/AST,分析三者在肝病类型诊断中的一致性.结果mAST活性在急性肝炎、重型肝炎、肝癌患者中均显著高于对照组,差异有统计学意义(P<0.05);急性肝炎、肝硬化、重型肝炎、肝癌患者的mAST/AST显著低于对照组,差异有统计学意义(P<0.05)。mAST对肝病的诊断效率较高,ROC曲线下面积达到0.897;mAST对重型肝炎的诊断效率最高,ROC曲线下面积达到0.753.mAST和AST用于诊断各种肝病类型时有较高的一致性.结论血清mAST活力能反映肝细胞坏死情况,对于肝病类型的临床分类有较高的价值.
Objective To investigate the clinical value of measuring mAST activity in the diagnosis of liver disease.Methods The serum mAST, 310 AST patients and 310 patients with liver disease and 75 healthy controls (control group) (P <0.05). Acute hepatitis, cirrhosis and severe hepatitis were significantly higher in patients with acute hepatitis, severe hepatitis and hepatocellular carcinoma than those in control group , MAST / AST in patients with liver cancer was significantly lower than the control group, the difference was statistically significant (P <0.05). MAST has a high diagnostic efficiency for liver disease, with an area under the ROC curve of 0.897. MAST has the highest diagnostic efficiency for severe hepatitis with an area under the ROC curve of 0.753. MAST and AST are used to diagnose various liver disease types with higher consistency. Conclusion Serum mAST activity can reflect the condition of hepatocellular necrosis and has a high value for the clinical classification of liver disease.