利福平、异烟肼均为临床治疗肺结核的一线药物。利福平抗菌谱广 ,对多种病原微生物均有抗菌活性 ,其中对生长缓慢或处于生长间歇期的结核菌有良好的抗菌作用 ,单独应用时 ,结核菌极易产生耐药性。异烟肼对结核菌有高度特异的抗菌作用 ,浓度较高时对增殖期结核菌有很强的杀菌作 Rifampicin, isoniazid are first-line drugs for the clinical treatment of tuberculosis. Rifampicin antibacterial spectrum wide, a variety of pathogenic microorganisms have antibacterial activity, which slow growth or in the intermittent growth of the Mycobacterium tuberculosis has a good antibacterial effect, when used alone, extremely susceptible to TB. Isoniazid has a high degree of specific antimicrobial activity against Mycobacterium tuberculosis, with high bactericidal activity against M. tuberculosis during the proliferative phase at high concentrations