【摘 要】
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A series of quinoline-3-carbonitrile derivatives were designed and synthesized.Their cytotoxicity in vitro against four cancer cell lines (A549,HT-29,MDA-MB-231
【机 构】
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Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education
论文部分内容阅读
A series of quinoline-3-carbonitrile derivatives were designed and synthesized.Their cytotoxicity in vitro against four cancer cell lines (A549,HT-29,MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay.The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line.Among them,compounds 7c,7e,11b,11f and 11g were more active than Gefitinb against SMMC-7721 cell line.
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