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目的探讨研究无创动态监测甘露醇联合通腑合剂在治疗大面积梗死患者脑水肿方面的临床效果与价值。方法 50例大面积脑梗死患者,按随机数字表法分为对照组和实验组,每组25例。对照组以甘露醇干预,实验组患者同时联合通腑合剂治疗。对两组患者在接受治疗前、治疗7 d后的脑水肿扰动系数、脑梗死病灶周围低密度容积情况进行对比分析。结果接受治疗前,两组患者脑水肿扰动系数、脑梗死病灶周围低密度容积均值对比差异无统计学意义(P>0.05);接受治疗7 d后,实验组患者脑水肿扰动系数为(8.1±0.5),脑梗死病灶周围低密度容积为(10.1±0.8)mm3,均明显低于对照组,组间对比差异有统计学意义(P<0.05)。结论甘露醇联合通腑合剂在治疗大面积梗死患者脑水肿方面的临床效果非常确切,可改善患者脑水肿症状,缩小脑梗死病灶面积,值得临床推广应用。
Objective To investigate the clinical effect and value of noninvasive dynamic monitoring of mannitol combined with Tongfu Mixture in treating brain edema in patients with large infarcts. Methods Fifty patients with large area cerebral infarction were randomly divided into control group and experimental group according to random number table method, with 25 cases in each group. Mannitol intervention in the control group, the experimental group patients at the same time Tongfu Mixture treatment. Before the treatment, the disturbance coefficient of cerebral edema and the low density volume around the cerebral infarction were compared between the two groups before treatment. Results Before treatment, there was no significant difference in the disturbance coefficient of cerebral edema between two groups and the average value of low density volume around cerebral infarction (P> 0.05). After 7 days of treatment, the disturbance coefficient of cerebral edema in experimental group was (8.1 ± 0.5). The volume of low density around cerebral infarction was (10.1 ± 0.8) mm3, which was significantly lower than that of the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion Mannitol combined with Tongfu Mixture has a very good clinical effect in treating brain edema in patients with large infarcts. It can improve the symptoms of cerebral edema and reduce the infarct size in patients with cerebral infarction, which is worthy of clinical application.