原发性干燥综合征(pSS)和原发性胆汁性胆管炎(PBC)具有许多相似的特征,常于同一患者中共存。近年来,环境及感染性因素在自身免疫性疾病发病机制中的重要作用得到越发深入的认识。EB病毒、巨细胞病毒、大肠埃希菌、幽门螺旋杆菌等感染性因素可能通过激活干扰素(IFN)途径和分子模拟途径参与pSS和PBC的发病和对疾病进程的影响,通过抑制病毒基因及相关抗原在机体内的表达可能为治疗提供新的策略。 Primary Sjogren’s syndrome (pSS) and primary biliary cholangitis (PBC) have many similarities and often coexist in the same patient. In recent years, the important role of environmental and infectious agents in the pathogenesis of autoimmune diseases has been further understood. Infectious factors such as Epstein-Barr virus, cytomegalovirus, Escherichia coli and Helicobacter pylori may be involved in the pathogenesis of pSS and PBC and the disease process by activating interferon (IFN) pathway and molecular mimicking pathway. By inhibiting viral genes and The expression of the relevant antigen in the body may provide a new strategy for treatment.