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为探索复方不育剂左炔诺孕酮-炔雌醚(EP-1)对雄性东方田鼠Microtus fortis的不育效果、适宜药剂浓度和生殖系统的恢复期等,采用一次性多个浓度组灌胃和多个时间段剖检的方法测定EP-1对雄性东方田鼠生殖的影响和药效持续时间。结果显示,不育剂EP-1对雄性东方田鼠具有明显的不育作用,但不育作用具有可逆性。试验组试鼠的睾丸系数、附睾系数降低,睾丸萎缩受损,精子密度与睾酮含量较对照组降低,且繁殖率下降。10、30、60 mg/kg处理组的雄性东方田鼠生殖系统恢复时间分别为40、55、60天左右,生殖恢复顺序为睾丸、附睾、精子密度。
In order to explore the infertility effects of levonorgestrel-ethynylestradiol (EP-1) on Microtus fortis in male voles (Microtus fortis), the appropriate drug concentration and reproductive system recovery period, The effect of EP-1 on the reproductive performance of male voles (Microtus Fortis) and its duration of action were determined by autopsy and multiple necropsy procedures. The results showed that the infertility agent EP-1 had obvious infertility effect on male voles, but the infertility effect was reversible. Test group rats testis coefficient, epididymal coefficient decreased, testicular atrophy damage, sperm density and testosterone levels lower than the control group, and the reproduction rate decreased. The reproductive system recovery time was 40, 55 and 60 days in 10, 30 and 60 mg / kg treatment groups respectively. The reproductive recovery order was testis, epididymis and sperm density.