特发性低促性腺激素性性功能低减(IHH)患者行GnRH脉冲疗法效果满意。促性腺激素(Gn)及性激素反应图形与正常月经周期相同。但多囊卵巢综合征(PCOS)患者疗效很差。为了弄清其潜在的内分泌机理并试予纠正,本文以IHH原发闭经患者反应作为标准,研究了PCOS患者对GnRH脉冲治疗的异常反应,并观察了用GnRH增效剂预先抑制后再用GnRH脉冲治疗的效果。结果:IHH组每周期排卵率为89%,妊娠率为18%;而PCOS未预先抑制(Pre-A)组则各为38%及8%。Pre-A组排卵周期的早卵泡期(EF)血 GnRH pulse therapy was satisfactory in patients with idiopathic hypogonadotropic hypofunction (IHH). Gonadotropin (Gn) and sex hormone response patterns and the normal menstrual cycle. However, polycystic ovary syndrome (PCOS) patients with poor efficacy. In order to clarify its potential mechanism of endocrine and try to correct, this paper, IHH primary amenorrhea patients as the standard response to study PCOS patients with GnRH pulse treatment of abnormal response and observed with GnRH synergist before inhibition of GnRH The effect of pulse therapy. RESULTS: The ovulation rate was 89% and the pregnancy rate was 18% in the IHH group and 38% and 8% in the Pre-A group. Pre-A group ovulation cycle early follicular phase (EF) blood