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目的探讨HPV感染与宫颈癌的关系。方法采用杂交捕获HPV-DNA检测144例宫颈病变患者中HPV感染、年龄分布状况。结果HPV总阳性率为41.7%,在慢性宫颈炎为8.3%,宫颈癌前病变为48.2%,宫颈癌为69.6%。三者中差异有显著性(P<0.05),宫颈癌前病变与宫颈癌HPV感染显著高于慢性宫颈炎。HPV感染在青年组与老年组及中年组与老年组比较有统计学差异(P<0.05)。结论HPV感染是宫颈癌前病变和宫颈癌的主要致病因素,青、中年妇女HPV感染比例较大。
Objective To investigate the relationship between HPV infection and cervical cancer. Methods The HPV infection and age distribution in 144 cases of cervical lesions were detected by hybridization HPV-DNA. Results The total positive rate of HPV was 41.7%, 8.3% in chronic cervicitis, 48.2% in cervical precancerous lesions and 69.6% in cervical cancer. The differences among the three groups were significant (P <0.05). HPV infection in cervical precancerous lesions and cervical cancer was significantly higher than that in chronic cervicitis. HPV infection in the youth group and the elderly group and the middle-aged group and the elderly group was statistically significant difference (P <0.05). Conclusion HPV infection is the main causative factor of cervical precancerous lesions and cervical cancer. The proportion of HPV infection among young and middle-aged women is larger.