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1969年英国学者Filipe首先以组织化学方法发现在大肠腺癌上皮与正常肠粘膜之间存在着一段过渡性粘膜组织,这种肠粘膜主要的组织化学特性表现为腺管上皮细胞内唾液酸粘蛋白(sialomucin)含量的增加和硫酸粘蛋白(sulphomucin)含量的减少或者消失,而肉眼或者组织学检查其结构正常,称这种在大肠癌旁发生区域性变化的粘膜为移行粘膜(transitional mucosa,TM)。现已知正常人结肠粘膜上皮细胞主要含有硫酸粘蛋白,若以高铁双胺——奥蓝(high iron diamine——alcian blue,HID-AB)组织化学染色呈棕黑色;而癌旁移行区粘膜上皮细胞主要
In 1969, the British scholar Filipe first discovered by histochemical methods that there was a transitional mucosal tissue between the adenocarcinoma epithelium and the normal intestinal mucosa. The main histochemical characteristics of the intestinal mucosa were sialic acid mucins in the ductal epithelium. The increase in the content of sialomucin and the decrease or disappearance of the sulphomucin content, but the structure of the sulphomucin is normal in the naked eye or histological examination. The mucosa that has undergone regional changes beside the colorectal cancer is the transitional mucosa (TM). ). It is known that normal human colonic mucosal epithelial cells mainly contain sulphate mucin, and histochemical staining with high iron diamine (alcian blue, HID-AB) is brownish black; The main epithelial cells