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目的：观察高原不同海拔梯度下脑内脂质过氧化物的代谢变化，进一步探讨高原脑水肿的发生机理。方法：取三个不同海拔梯度下脑组织匀浆化学法测定脑内超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）和谷胱甘肽（ＧＳＨ）。结果：小鼠急进高海拔区后，随着海拔升高，ＳＯＤ含量逐渐升高，ＭＤＡ始终不变，但ＧＳＨ－ＰＸ和ＧＳＨ在进入中海拔区后增高，进入高海拔后ＧＳＨ－ＰＸ明显降低，而ＧＳＨ明显增高，差异均非常显著（Ｐ＜ ０．０１）。小鼠由低海拔区急进高海拔区后脑内ＳＯＤ水平随着时间延长呈增高趋势，ＣＸＨ—ＰＸ水平在进入高原第５ 天开始呈持续下降，ＧＳＨ水平从进入高原后的第７天开始上升，直到进入高原后的第１１ 天达到高峰，而后略有下降，但仍高于第７天的水平。实验结果同时表明，高海拔区不同时间暴露下脑组织含水量与脑内ＳＯＤ、ＧＳＨ和ＭＤＡ均呈正相关关系，与脑内ＧＳＨ－ＰＸ呈负相关关系。结论：高原环境下脑内过高的脂质过氧化反应与高原脑水肿发病有一定关系
OBJECTIVE: To observe the changes of brain lipid peroxides under different altitudes in the plateau, and to explore the pathogenesis of plateau cerebral edema. Methods: Brain homogenates were used to measure the contents of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-PX) and glutathione Glycopeptide (GSH). Results: After the mice reached the altitude, the content of SOD gradually increased and the MDA remained unchanged. However, GSH-PX and GSH increased after entering the middle-altitude area and decreased significantly after entering the high altitude , While the GSH was significantly higher, the difference was significant (P <0.01). The level of SOD in brain gradually increased with the increase of time from low altitude to high altitude. The level of CXH-PX began to decline continuously from the 5th day after entering the plateau. The level of GSH began to increase from the 7th day after entering the plateau, Reached its peak on the eleventh day after entering the plateau, then declined slightly, but still higher than the level on the seventh day. The experimental results also showed that the water content of brain tissue at different time zones exposed to high altitude showed a positive correlation with SOD, GSH and MDA in the brain and a negative correlation with GSH-PX in the brain. CONCLUSIONS: Hypercapnic lipid peroxidation is associated with the pathogenesis of high altitude brain edema at high altitude