论文部分内容阅读
目的 应用多普勒超声检查评价川崎病患儿冠状动脉 (简称冠脉 )循环功能的损伤。方法 应用经胸多普勒超声检测经静脉注射三磷酸腺苷 [16 0 μg/ (kg·min) ]前和第 6min时 32例川崎病患儿和 2 5例正常对照儿童左冠脉前降支血流 ,估算冠脉血流储备 (CFR) ,即舒张期峰值流速比 (D/RPDV)。结果 基础状态各组冠脉血流速度差异均无显著性 ,注射ATP后 ,正常对照组冠脉血流速度高于川崎病组 (1 39± 0 31、1 0 2± 0 2 3,P <0 0 1)。川崎病患儿冠脉血流储备明显低于正常儿童(2 91± 0 96、4 5 0± 0 92 ,P <0 0 1) ,与正常对照组比较差异有显著性。川崎病冠脉扩张组与无扩张组患儿CFR差异无显著性 (2 85± 0 79、2 97± 0 88,P >0 0 5 )。随访复查中 ,CFR降低在病程第 3、6、8个月分别为 96 %、6 4%、32 %。结论 川崎病存在冠脉循环功能的损伤。CFR降低是川崎病冠脉病变的病理生理表现。多普勒超声检测冠脉血流评估CFR具有较高的应用价值。
Objective To evaluate the function of coronary artery (coronary artery) circulatory function in children with Kawasaki disease by Doppler echocardiography. Methods Thirty-two children with Kawasaki disease and 25 normal children with left anterior descending coronary artery were detected by transthoracic Doppler ultrasonography before and 16 minutes after intravenous injection of adenosine triphosphate ([16 0 μg / (kg · min)]) , Estimated coronary flow reserve (CFR), the diastolic peak flow ratio (D / RPDV). Results There was no significant difference in the coronary blood flow velocity between the groups in the basal group. After the injection of ATP, the coronary flow velocity in the normal control group was higher than that in the Kawasaki disease group (399.131 ± 102.33, P < 0 0 1). Coronary flow reserve in children with Kawasaki disease was significantly lower than that of normal children (2 91 ± 0 96, 45 0 ± 0 92, P 0 01), which was significantly different from that of the normal controls. There was no significant difference in CFR between Kawasaki disease and non-dilatation group (2 85 ± 0 79,2 97 ± 0 88, P 0 05). During the follow-up review, the reduction of CFR was 96%, 64%, 32% at the 3rd, 6th, and 8th months respectively. Conclusion Kawasaki disease has coronary artery injury. CFR reduction is Kawasaki disease pathological changes of coronary artery. Doppler ultrasound examination of coronary blood flow assessment of CFR has a high value.