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苔藓纤维出芽是颞叶癫痫突触重组的主要表现。出芽的苔藓纤维在颗粒细胞间形成兴奋性环路,使颗粒细胞产生同步化电活动的阈值降低,也可经海马结构内的传导通路,使海马结构在传出途径上的电活动增强,从而导致反复自发性癫痫发作的发生。钙离子作为一种信使参与多种细胞功能活动的调节,钙通道功能的改变可引起细胞内外钙离子浓度的变化,而细胞内高钙和细胞外低钙均可诱发神经电活动紊乱,因此钙稳态在癫痫发生发展及海马突触重组的形成中起重要作用。
Mossy fiber sprouting is a major manifestation of temporal lobe epilepsy synaptic remodeling. The sprouted mossy fiber forms an excitatory loop between granulosa cells, allowing the granulosa cells to generate synchronized thresholds of reduced electrical activity, as well as increasing the electrical activity of the hippocampal formation in the outgoing pathway through the conduction pathways in the hippocampal formation Lead to the occurrence of recurrent spontaneous seizures. Calcium as a messenger involved in the regulation of a variety of cellular functions and activities, changes in calcium channel function can cause changes in intracellular and extracellular calcium concentration, intracellular and extracellular low calcium can induce neuronal electrical activity disorders, so calcium Steady state plays an important role in the development of epilepsy and the formation of hippocampal synaptic remodeling.