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目的：研究ＩＧＦ—Ⅱ ｍＲＮＡ在肾母细胞瘤中的表达。方法：用原位杂交方法检测４２例肾母细胞瘤在不同病理组织类型中的表达。结果： ４２例肾母细胞瘤中有 ２８例呈高表达， １０例正常组织呈低表达，两组比较有显著差异（ Ｐ＜ ０． ０１），其中以胚基细胞为主型肾母细胞瘤的ＩＧＦ－ⅡｍＲＮＡ的表达高于上皮细胞优势型和间质细胞优势型的肾母细胞瘤（Ｐ＜０． ０１；在低分化间变型肾母细胞瘤中ＩＧＦ—ⅡｍＲＮＡ表达水平显著高于无间变型肾母细胞瘤（Ｐ＜０．０５）。结论：ＩＧＦ—Ⅱ ｍＲＮＡ表达水平的高低与肾母细胞瘤的分化程度呈负相关性且ＩＧＦ—Ⅱ在肾母细胞瘤的增殖分化中起重要的调节作用。
Objective: To study the expression of IGF-Ⅱ mRNA in Wilms’ tumor. Methods: The expression of nephroblastoma in 42 cases of different pathological types was detected by in situ hybridization. Results: In 42 cases of nephroblastoma, 28 cases were highly expressed and 10 cases were normal tissues with low expression (P <0.01). The majority of blastocyst-based nephroblastoma (P <0.01). The expression of IGF-ⅡmRNA in the poorly differentiated metaxant nephroblastoma was significantly higher than that in the all-trans form (P0.05) .Conclusion: The expression level of IGF-Ⅱ mRNA is negatively correlated with the degree of differentiation of nephroblastoma and IGF-Ⅱ plays an important role in the proliferation and differentiation of nephroblastoma Regulatory effect.