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显微成像技术通过帮助描述疾病过程及在此过程中可能进行干预的潜在治疗方法,可进一步加快药物发现过程。最近的一些新技术和对已有技术的改进集中解决了过去显微成像技术应用的技术难点,即增加了显微成像技术的空间分辨率,提高了组织穿透率、跨越机体组织障碍的能力,增加了实验通量。本文集中介绍最近显微成像技术一些值得注意的发展趋势,包括超显微技术的发展,多光子技术引入,纤维光学显微技术和自动成像技术以及应用于高内涵筛选的图像分析技术。总之,这些技术进步不仅仅加速了早期药物发现中已有的实验测定和疾病模型,还催生了许多新的测定方法和疾病模型。
Microscopic imaging can further accelerate the drug discovery process by helping to characterize the disease process and potential treatments that may intervene in the process. Some recent new technologies and advances in the prior art have focused on solving the technical difficulties of past microscopic imaging applications by increasing the spatial resolution of the microscopic imaging technology, increasing the tissue penetration rate and the ability to cross the body tissue disorders , Increasing the experimental throughput. This article focuses on some of the most noteworthy trends of recent microscopic imaging technologies, including the development of super-microscopy, introduction of multiphoton technology, fiber optical microscopy and automated imaging, and image analysis techniques for high-content screening. In conclusion, these advances have not only accelerated the experimental and disease models already available in early drug discovery, but have also led to many new assays and disease models.