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目的:观察中药制剂联合维生素D3(Vit D3)预防毛细支气管炎后喘息的临床效果。方法:将确诊为毛细支气管炎的住院患儿107例,按随机数字表分成治疗组54例和对照组53例。治疗组给予口服中药和Vit D3,中药制剂[黄芪、党参、白术、茯苓、(西)防风、甘草]每日1剂,分2次服用,每月服10 d,Vit D3400 U/d,均连服3个月;对照组给予吸入丙酸氟替卡松气雾剂。随访1年,统计两组发生喘息性疾病的病例数、发作次数、出院后1年行肺功能检测。结果:1年内对照组发生喘息24例(45.28%),治疗组发生喘息14例(25.92%),两组比较差异有统计学意义(P<0.05);治疗组潮气量、达峰时间比、达峰容积比、25%呼气流速等肺功能指标明显改善,与对照组比较差异有统计学意义(P<0.05)。结论:中药联合维生素D3治疗能改善毛细支气管炎后气道阻塞、预防反复喘息等症状,疗效确切,值得临床推广应用。
OBJECTIVE: To observe the clinical effect of traditional Chinese medicine (TCM) combined with Vit D3 in the prevention of wheezing after bronchiolitis. Methods: A total of 107 hospitalized children diagnosed with bronchiolitis were divided into treatment group (n = 54) and control group (n = 53) according to random number table. The treatment group was given orally with traditional Chinese medicine and Vit D3. Chinese medicine (Astragalus root, Codonopsis, Atractylodes, Poria cocos, Wind west, Glycyrrhiza glabra] was given once a day for two times daily for 10 days and Vit D3400 U / d Even for 3 months; the control group was inhaled fluticasone propionate aerosol. The patients were followed up for 1 year. The number of cases of asthmatic disease and the number of seizures in both groups were counted. One year after discharge, pulmonary function tests were performed. Results: In one year, 24 cases (45.28%) wheezed in the control group and 14 cases (25.92%) wheezed in the treatment group, the difference between the two groups was statistically significant (P <0.05). The tidal volume, peak time, Peak volume ratio, 25% expiratory flow rate and other lung function indicators improved significantly compared with the control group was statistically significant (P <0.05). Conclusion: The combination of Chinese medicine and vitamin D3 can improve airway obstruction after bronchiolitis and prevent recurrent wheezing and other symptoms. The curative effect is exact and worthy of clinical application.