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抗氯喹恶性疟已波及50余国,自从60年代起美国Walter Reed 军事研究院为开发新的抗疟药,共筛选了25万个化合物,其中以甲氟喹和氯氟菲醇(halofan-trine)两药为最好,甲氟喹已在东南亚应用,而本文介绍的氯氟菲醇则尚在试验中。该药从1974年起曾在志愿者中进行临床试验,1984年起进行商业性开发研究,在1000名病人中作进一步临床试验,并在法国、象牙海岸、多哥和刚果已作为抗疟药登记注册。
Anti-chloroquine falciparum malaria has spread to more than 50 countries, since the 1960s Walter Reed Military Research Institute to develop new antimalarial drugs, a total of 250,000 compounds were screened, with mefloquine and chlorofluorfen alcohol (halofan-trine ) Two drugs as the best, mefloquine has been applied in Southeast Asia, and this article describes chlorofluorfen alcohol is still under test. The drug has been tested in volunteers since 1974 and commercial development studies have been conducted since 1984 for further clinical trials in 1,000 patients and as antimalarial drugs in France, Ivory Coast, Togo and the Congo Registration.