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细胞的恶性变化常伴有酶的改变,这可以用组织化学方法加以证实,并作为恶性肿瘤的有用的标志物.在胃癌患者的肿瘤组织和未累及的胃粘膜中,由于厌氧代谢逐步增强,胃液内的乳酸脱氢酶(LDH)总活性在胃癌时升高,LDH同工酶的分布亦有所改变.胃癌组织中的β-葡糖苷酸酶活性比未累及的胃粘膜中的要高.胃癌患者胃液中的β-葡糖苷酸酶水平升高.在本实验中,作者研究了胃液LDH和β-葡糖苷酸酶值探索诊断胃癌的可能性.对113名消化不良患者进行了研究.其方法是,将所有患者均进行双对照钡餐检查和内窥镜活检,待确诊后进行剖腹探查.胃液标本是在一夜禁食之后,通过胃检管或在内窥镜检查前获取.为抽取静
Malignant changes in cells are often accompanied by changes in enzymes, which can be confirmed by histochemical methods, and serve as useful markers of malignancy. In cancerous tissues of patients with gastric cancer and non-involved gastric mucosa, anaerobic metabolism is gradually enhanced. The total activity of lactate dehydrogenase (LDH) in gastric juice was increased in gastric cancer, and the distribution of LDH isoenzymes was also changed. The activity of β-glucuronidase in gastric cancer tissue was higher than that in unoccupied gastric mucosa. High. Gastric fluid β-glucuronidase levels in gastric cancer patients are elevated. In this experiment, the authors studied the possibility of gastric juice LDH and β-glucuronidase values in the diagnosis of gastric cancer. The study. The method was to perform double-control barium meal examination and endoscopic biopsy for all patients. After diagnosis, laparotomy was performed. Gastric fluid samples were obtained by gastric tube or before endoscopy after overnight fasting. To extract static