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外分泌液(唾液、泪液、乳汁等)中的免疫球蛋白以IgA为主。人类IgA包括三种不同形式:IgA单体;IgA多聚体,两个或两个以上的单体通过二硫键与J链连接;分泌型IgA,包含2～4个以二硫键连接的单体、J链和分泌片。分泌型IgA是两种不同类型细胞的产物。分泌组织的上皮下浆细胞能产生含有J链的多聚IgA,上皮细胞能合成分泌片,它是IgA的表面受体,二者组成的复合物被吞饮,并以小泡的形式在胞浆内运输。小泡与细胞膜融合,在上皮细胞的腔面释放出终产物分泌型IgA。在肠道、支气管、鼻粘膜、乳腺、唾液腺和泪
IgA-based immunoglobulins in exocrine fluids (saliva, tears, milk, etc.). Human IgA comprises three different forms: IgA monomers; IgA multimers, two or more monomers linked to the J chain by disulfide bonds; secretory IgA, containing two to four disulfide-linked Monomer, J chain and secretion tablets. Secretory IgA is the product of two different types of cells. Secretion of epithelial cells under the plasma cells can produce J-chain containing poly IgA, epithelial cells can synthesize secretion pieces, it is IgA surface receptors, the composition of the two is swallowed drink, and in the form of vesicles in the cell Slurry transport. The vesicles fuse with the cell membrane, releasing end-product secreted IgA on the luminal side of the epithelium. In the gut, bronchus, nasal mucosa, breast, salivary glands and tears