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本文用新生大鼠制备的窒息模型,研究中药丹参注射液抗急性缺氧性脑损伤的机理。实验结果表明,窒息组脑组织中的LPO和Ca~(2+)含量为39.27±5.37和42.14±18.68,同丹参组33.67±5.57和22.00±14.83间差异具显著性(P<0.05-0.01),脑组织学病理改变程度重于丹参组;而丹参组和对照组,上述指标的差异不具显著性。提示丹参通过抗脂质过氧化和减少Ca~(2+)内流等机制,发挥对缺氧脑细胞的保护作用。
In this paper, the mechanism of anti-anoxic brain injury induced by Salvia miltiorrhiza injection was studied using the asphyxiation model prepared from neonatal rats. The experimental results showed that the contents of LPO and Ca 2+ in brain tissue of asphyxia group were 39.27±5.37 and 42.14±18.68, and there were significant differences between Salvia miltiorrhiza group (33.67±5.57 and 22.00±14.83) (P<0.05-0.01). The degree of pathological changes in brain histology was more severe than that in Salvia miltiorrhiza. However, the differences between the above parameters in Salvia miltiorrhiza group and control group were not significant. It is suggested that salvia miltiorrhiza can protect hypoxic brain cells through anti-lipid peroxidation and reducing Ca 2+ influx.