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目的调查皮肤性病门诊泌尿生殖道感染患者沙眼衣原体(CT)和支原体感染情况及支原体培养加药敏分析。方法对666例泌尿生殖道感染患者用PCR法检测沙眼衣原体,用微量肉汤稀释法检测解脲支原体(Uu)和人型支原体(Mh)并进行10种抗菌素的药敏试验。结果 666例泌尿生殖道感染者中衣原体阳性共56例,总阳性率为8.41%,女性患者阳性率为8.06%,男性患者阳性率为8.54%,男女感染率差异无统计学意义(P>0.05)。检出支原体185例,全部为解脲支原体,总阳性率为28.78%,女性患者阳性率为44.62%明显高于男性患者阳性率21.25%,男女感染率差异有统计学意义(P<0.05)。解脲支原体对强力霉素敏感率最高,其次为克拉霉素及交沙霉素;敏感率最低的为红霉素及环丙沙星,其次为可乐必妥。结论皮肤性病门诊泌尿生殖道感染患者中,支原体感染率高于衣原体,以脲解支原体为主,支原体对不同种类抗生素敏感性不同,建议根据药敏结果选择治疗药物。
Objective To investigate the infection of Mycoplasma chlamydia (CT) and mycoplasma in patients with genitourinary tract infection and the analysis of mycoplasma infection and drug susceptibility in dermatology clinic. Methods Chlamydia trachomatis was detected by PCR in 666 patients with genitourinary tract infection. Uu and Mh were tested by micro broth dilution method and drug susceptibility test of 10 antibiotics was performed. Results The positive rate of chlamydia in 666 cases of genitourinary tract infection was 56.1%, the positive rate was 8.41%, the positive rate was 8.06% in female patients and 8.54% in male patients. There was no significant difference between male and female infection rates (P> 0.05 ). 185 cases of mycoplasma were detected, all were Ureaplasma urealyticum, the total positive rate was 28.78%. The positive rate of female patients was 44.62%, which was significantly higher than that of male patients (21.25%). The infection rate of male and female was statistically significant (P <0.05). Ureaplasma urealyticum was the most sensitive to doxycycline, followed by clarithromycin and jasminemycin; the lowest susceptibility was erythromycin and ciprofloxacin, followed by colabitone. Conclusion The prevalence of mycoplasma infection in patients with genitourinary tract infections in dermatology clinics is higher than that in chlamydia. Mycoplasma urealyticum is predominant. Mycoplasma is different in sensitivity to different antibiotics. It is suggested that drugs should be selected according to drug susceptibility results.