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目的:观察实施程序化镇痛镇静对降低呼吸机相关性肺炎(VAP)发生率的有效性。方法:选取庐江县人民医院2018年6月至2019年5月收治的气管插管机械通气患者45例为观察组，按照2018年最新《中国成人ICU镇痛和镇静治疗指南》，制定并执行以浅镇静为目标导向性的程序化镇痛镇静流程，规定医生制定镇痛镇静的方案和目标，护士动态评估患者镇痛镇静目标情况，并根据评估结果调节药物剂量，感控办督查流程实施。回顾分析2018年1-5月收治的气管插管机械通气患者45例为常规组，按照传统方法使用药物镇静镇痛治疗，遵医嘱进行药物剂量调整。比较两组患者机械通气时间、VAP发生率以及住重症医学科(ICU)时间。结果:观察组患者VAP发生率为11.11%(5/45)，常规组患者VAP发生率为31.11%(14/45)，两组差异有统计学意义(χn 2＝4.270，n P0.05)。n 结论:机械通气患者实施程序化镇痛镇静能有效减少VAP的发生。“,”Objective:To observe and analyze the effectiveness of programmed analgesia and sedation in ICU on reduction of the incidence of ventilator-associated pneumonia (VAP).Methods:Forty-five tracheal intubation patients admitted in ICU of the People's Hospital of Lujiang County from June 2018 to May 2019 were selected as the observation group.Infection Control Office organized a conference on ICU quality control in the ICU department to train the latest 2018 Chinese Adult ICU Analgesia and Sedation Treatment Guidelines, formulated and implemented a program-oriented analgesia and sedation process with shallow sedation as the goal, which stipulated that doctors develop analgesia and sedation plans and goals, nurses dynamically assess the patients' analgesia and sedation target and adjust drugs based on the evaluation results, and Infection Control Office supervised the implement of process.Forty-five patients with tracheal intubation treatment from January 2018 to May 2018 were included in the conventional group.Drug sedation and analgesia were used in accordance with traditional methods, and drug dose adjustment was performed according to doctor's orders.The time of mechanical ventilation, the incidence of VAP, and the time of ICU stay were compared between the two groups.Results:The incidence of VAP in the observation group was 11.11%(5/45), which in the conventional group was 31.11%(14/45), and the difference was statistically significant between the two groups(χn 2=4.27, n P0.05).n Conclusion:Programmed analgesia and sedation can effectively reduce the incidence of VAP in patients with mechanical ventilation.