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胰岛素抵抗和B细胞分泌功能缺陷是2型糖尿病(T2DM)发生的重要生理学基础,近年来研究显示,脂代谢紊乱在其发病中起着重要的作用。脂毒性(lipotoxici-ty)是指血中游离脂肪酸(FFA)水平长期升高,超过脂肪组织储存能力和各组织对FFA的氧化能力,使过多的FFA以甘油三酯(TG)的形式沉积?
Insulin resistance and B cell secretory function defects are important physiological basis of type 2 diabetes mellitus (T2DM). Recent studies have shown that lipid metabolism disorders play an important role in the pathogenesis of T2DM. Lipotoxicity is defined as the long-term increase in the level of free fatty acids (FFA) in the blood that exceeds the capacity of adipose tissue storage and the ability of each tissue to oxidize FFA, causing excess FFA to be deposited as triglycerides (TG) ?