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目的:研究NGF及其受体TrkA在子宫腺肌病患者的异位内膜与在位内膜组织的表达情况及与痛经的关系。方法:采用免疫组化MaxVision法检测子宫腺肌病异位内膜(30例)、在位内膜(30例)、正常子宫内膜(19例)标本中NGF、TrkA蛋白的表达,分析其表达差异及与痛经的关系。结果:①子宫腺肌病异位内膜组NGF、TrkA表达显著高于正常内膜组(P<0.01),在位内膜组NGF、TrkA表达显著高于正常内膜组(P<0.01),子宫腺肌病异位内膜组NGF、TrkA表达与在位内膜组无显著差异。②子宫腺肌病异位内膜组NGF、TrkA表达与痛经强度评分呈正相关(相关系数r=0.637,P=0.000;r=0.662,P=0.000)。结论:NGF及其受体TrkA在子宫腺肌病中高表达可能参与子宫腺肌病发病机制,而且可能与痛经有关。
Objective: To investigate the expression of NGF and its receptor TrkA in ectopic endometrium and eutopic endometrium in patients with adenomyosis and its relationship with dysmenorrhea. Methods: The expression of NGF and TrkA in ectopic endometrium (30 cases), eutopic endometrium (30 cases) and normal endometrium (19 cases) were detected by immunohistochemistry MaxVision method. Expression Difference and Its Relationship with Dysmenorrhea. Results: ① The expression of NGF and TrkA in ectopic endometrium was significantly higher than that in normal endometrium (P <0.01), while the expression of NGF and TrkA in eutopic endometrium was significantly higher than that in normal endometrium (P <0.01) , Adenomyosis ectopic endometrium group NGF, TrkA expression and eutopic endometrium group no significant difference. ② The expression of NGF and TrkA in ectopic endometrium of adenomyosis was positively correlated with the score of dysmenorrhea (r = 0.637, P = 0.000; r = 0.662, P = 0.000). Conclusion: NGF and its receptor TrkA overexpression in adenomyosis may be involved in the pathogenesis of adenomyosis, and may be related to dysmenorrhea.