代谢综合征(metabolic syndrome,MetS)与胆石病的发生密切相关,但MetS状态下胆石病发生的具体机制尚未明了,现就MetS时FOXO1对胆结石形成的调节作用作一阐述。胆石病与MetS的关系胆囊胆固醇结石病(简称胆石病)是临床最常见的疾病之一。在发达国家,胆石病的发病率为10%~15%~([1]),且已成为个人及国家的沉重医疗负担。在我国,胆石病的发病率呈逐 The metabolic syndrome (MetS) is closely related to the occurrence of gallstone disease. However, the specific mechanism of gallstone disease under the condition of MetS is unclear. The regulation of FOXO1 on the formation of gallstone in MetS is described. Cholelithiasis and MetS gallstone gallstone disease (referred to as cholelithiasis) is one of the most common clinical disease. In developed countries, the incidence of gallstone disease is 10% ~ 15% ~ ([1]), and has become a heavy medical burden on individuals and countries. In our country, the incidence of gallstone disease was by