论文部分内容阅读
目的探讨早发型重度子痫前期患者血清中高密度脂蛋白(HDL)水平的变化及其在发病中的临床意义。方法选择2011-11-01至2013-10-01于青岛市市立医院产科住院的45例早发型重度子痫前期患者为早发型重度子痫前期组,同期50例正常健康孕妇作为正常妊娠组。检测两组孕妇血清中HDL、载脂蛋白A1含量及抗心磷脂抗体(ACA)IgG、IgM滴度。结果早发型重度子痫前期组患者血清中HDL含量和ACA阳性率均高于正常妊娠组,而载脂蛋白A1含量较正常妊娠组降低,两组差异有统计学意义(P<0.05);HDL含量与ACA滴度两组之间无明显相关性。结论高密度脂蛋白可能与早发型重度子痫前期发病有关。
Objective To investigate the changes of serum high density lipoprotein (HDL) in patients with early-onset severe preeclampsia and its clinical significance. METHODS: Forty-five patients with early-onset severe preeclampsia hospitalized in Qingdao Municipal Hospital from 2011-11-01 to 2013-10-01 were premature-onset severe preeclampsia group and 50 normal healthy pregnant women as normal pregnancy group. Serum HDL, apolipoprotein A1 and anti-cardiolipin antibodies (ACA) IgG and IgM titers were detected in two groups. Results Serum HDL level and ACA positive rate in patients with early-onset severe preeclampsia were higher than those in normal pregnancy group, while the content of apolipoprotein A1 was lower than that in normal pregnancy group (P <0.05). HDL There was no significant correlation between content and ACA titer between the two groups. Conclusion High-density lipoprotein may be associated with early onset of severe preeclampsia.