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目的探讨TRAIL及其受体TRAIL-R1、TRAIL-R2、TRAIL-R3、TRAIL-R4在子宫肌瘤发病机制中的作用。方法采用免疫组织化学法,测定子宫肌瘤组和对照组中TRAIL及其受体TRAIL-R1、TRAIL-R2、TRAIL-R3、TRAIL-R4的表达。结果 TRAIL-R1、TRAIL-R2在子宫肌瘤组织中的表达显著高于正常子宫平滑肌组织,肌瘤越大阳性强度表达越强,与年龄大小无关;而TRAIL-R3、TRAIL-R4在正常子宫平滑肌组织与子宫肌瘤组织中的阳性表达率相似,但肌瘤越大阳性强度表达反而越低,与年龄大小无关。结论 TRAIL在子宫肌瘤中的表达显著高于正常子宫组织,肌瘤越大阳性强度表达越强,其在子宫肌瘤组织中高表达,这提示着子宫肌瘤的发生发展过程中存在TRAIL的增加,由此造成TRAIL与其死亡受体结合所诱导的凋亡增加,促进肌瘤组织的增殖,由此参与子宫平滑肌瘤的发病机制。
Objective To investigate the role of TRAIL and TRAIL-R1, TRAIL-R2, TRAIL-R3 and TRAIL-R4 in the pathogenesis of uterine fibroids. Methods The expressions of TRAIL-R1, TRAIL-R2, TRAIL-R3 and TRAIL-R4 in uterine fibroid group and control group were determined by immunohistochemistry. Results The expression of TRAIL-R1 and TRAIL-R2 in uterine fibroids was significantly higher than that in normal uterine smooth muscle tissues. The more the fibroids were, the stronger the positive intensity expression was, which was not related to the age. TRAIL-R3 and TRAIL- Smooth muscle and uterine fibroids in the positive expression rate was similar, but the larger the positive expression of fibroids but lower, regardless of age. Conclusions The expression of TRAIL in uterine fibroids is significantly higher than that in normal uterine tissues. The higher the positive expression of fibroids, the higher the expression of TRAIL in uterine fibroids, which indicates the increase of TRAIL during the development of uterine fibroids , Resulting in increased apoptosis induced by the binding of TRAIL to its death receptor and promotion of fibroid tissue proliferation, thereby participating in the pathogenesis of uterine leiomyomas.