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目的 :观察十二指肠溃疡病人急性抑酸后胃内 p H升高是否影响体表胃电活动。 方法 :选择 12例胃镜诊断的十二指肠溃疡活动期患者 ,并以 10例健康人作为对照。p H电极经鼻放入胃内 ,同时记录胃内 p H值和体表胃电。在空腹时 (基础状态 )、静脉注射生理盐水后 (生理盐水对照 )和静脉注射 Famotidine40 m g使胃内 p H≥ 7时 (p H≥ 7期 ) ,分别记录体表胃电30 m in。用计算机频谱分析计算胃电参数。 结果 :十二指肠溃疡病人基础状态胃电主频率、正常胃慢波百分比明显低于健康人 (P<0 .0 5 ) ;十二指肠溃疡病人在 p H≥ 7期胃电主频率、主频率不稳定系数 (DFIC)和正常胃慢波百分比显著高于生理盐水对照 (P<0 .0 5 ) ;p H≥ 7期 /基础状态的胃电主功率比 (1.87± 0 .2 4)明显高于生理盐水对照 /基础状态之比值 (1.0 2± 0 .15 ) (P<0 .0 1)。 结论 :十二指肠溃疡病人存在胃电活动异常 ,急性抑酸使胃内 p H升高可增强其胃电功率和改善胃电节律紊乱。
OBJECTIVE: To observe whether elevated p H in the stomach after acute acid suppression of patients with duodenal ulcer affects the gastric electrical activity. Methods: 12 patients with active stage of duodenal ulcer diagnosed by gastroscope were selected, and 10 healthy people were taken as control. The p H electrode was placed nasally into the stomach, while the p H value in the stomach and the gastric electrical activity on the body surface were recorded. In the fasting (basal state), intravenous injection of saline (saline control) and intravenous injection of Famotidine 40 m g gastric p H ≥ 7 (p H ≥ 7), were recorded on the surface of the stomach electrical 30 m in. Gastric parameters were calculated using computerized spectrum analysis. Results: The basal state of duodenal ulcer patients was significantly lower than that of healthy subjects (P <0.05), and the percentage of normal gastric slow wave was significantly lower in patients with duodenal ulcer (P <0.05) , The main frequency instability coefficient (DFIC) and the percentage of normal gastric slow wave were significantly higher than those of the saline control group (P <0.05); the main electrovaporization power of p H≥7 / basic state (1.87 ± 0.2 4) was significantly higher than the saline control / basal ratio (1.0 2 ± 0.15) (P <0.01). Conclusion: There is abnormal gastric electrical activity in patients with duodenal ulcer. Acute acid suppression can increase gastric electrical power and improve gastric electrical rhythm disorder.