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目的:采用正交试验设计优选四神结肠靶向片的提取工艺。方法:以乙醇体积分数、溶媒用量、提取次数及提取时间为考察因素,以补骨脂素、异补骨脂素、吴茱萸碱、吴茱萸次碱的提取率及出膏率为考察指标,采用L9(34)正交试验优选四神结肠靶向片的HPLC含量测定及提取工艺。结果:最佳提取工艺为加8倍量60%乙醇回流提取3次,每次提取1.5 h。结论:优选提取工艺合理,提取效率高,适用于工业生产。
OBJECTIVE: To optimize the extraction process of Sijin colon targeting tablets by orthogonal design. Methods: The ethanol volume fraction, the amount of solvent, extraction times and extraction time were investigated. The extraction rate of Psoralen, Isopsoralen, Evodiamine, Rutaecarpine, (34) Orthogonal test for the determination of Tetra God colon targeting tablets HPLC content and extraction process. Results: The best extraction process was adding 8 times the amount of 60% ethanol reflux extraction three times, each extraction 1.5 h. Conclusion: The optimum extraction process is reasonable, extraction efficiency, suitable for industrial production.