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目的分析肺功能测定在哮喘—慢性阻塞性肺疾病重叠综合征(ACOS)中的应用价值。方法选取2014年10月-2016年12月于医院就诊住院的支气管哮喘、慢性阻塞性肺疾病、ACOS患者共90例。将支气管哮喘患者30例作为A组,慢性阻塞性肺疾病患者30例作为B组,ACOS患者30例作为C组,比较3组患者的肺功能、呼出气一氧化氮(Fe NO)、并做肺功能检测,包括用力呼气量占用力肺活量比值(FEV1%)变异率、50%呼气流量、残气量/肺总量(RV/TCL)等。结果 B组、C组FEV1%、FEF50%、Fe NO水平均低于A组,RV/TCL水平高于A组(P<0.05),C组FEF50%低于B组,Fe NO水平高于B组,差异均有统计学意义(P<0.05)。但B组、C组间FEV1%、RV/TCL%水平无差异(P>0.05)。3组患者吸入支气管扩张剂后,A组FEV1变异率为(16.7±10.0),B组为(4.5±3.9),C组为(20.0±17.4)。B组FEV1变异率小于A组和C组,差异有统计学意义(P<0.05)。A、C组FEV1变异率差异无统计学意义(P>0.05)。结论诊断哮喘、慢性阻塞性肺疾病、ACOS 3种疾病时,除了患者的临床症状外,肺功能表现也是重要的指标,因肺功能检测的无创性,操作简单,值得在基层医院推广。
Objective To analyze the value of pulmonary function test in asthma - chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods A total of 90 patients with bronchial asthma, chronic obstructive pulmonary disease and ACOS who were hospitalized in the hospital from October 2014 to December 2016 were selected. 30 patients with bronchial asthma as group A, 30 patients with chronic obstructive pulmonary disease as group B and 30 patients with ACOS as group C, lung function was compared between the three groups, and exhaled NO (Fe NO) Pulmonary function tests included variability of forced expiratory volume (FEV1%), 50% expiratory flow, residual volume / total lung volume (RV / TCL), and others. Results The levels of FEV1%, FEF50% and FeNO in group B and group C were lower than those in group A, and RV / TCL were higher than those in group A (P <0.05). The FEF50% in group C was lower than that in group B, Group, the difference was statistically significant (P <0.05). However, there was no difference in FEV1% and RV / TCL% between group B and group C (P> 0.05). After 3 inhalation of bronchodilators, FEV1 mutation rate in group A was (16.7 ± 10.0), in group B (4.5 ± 3.9) and in group C (20.0 ± 17.4). The variation rate of FEV1 in group B was less than that in group A and group C, the difference was statistically significant (P <0.05). There was no significant difference in FEV1 mutation rate between group A and group C (P> 0.05). Conclusion In the diagnosis of asthma, chronic obstructive pulmonary disease and ACOS, lung function is an important index in addition to the clinical symptoms of patients. Because of the noninvasive and simple operation of pulmonary function tests, it is worth to be popularized in primary hospitals.