Inland lakes and alpine glaciers are important water resources on the Tibetan Plateau. Understanding their variation is crucial for accurate evaluation and prediction of changes in water supply and for retrieval and analysis of climatic information. Data from previous research on 35 alpine lakes on the Tibetan Plateau were used to investigate changes in lake water level and area. In terms of temporal changes, the area of the 35 alpine lakes could be divided into five groups: rising, falling-rising, rising-falling, fluctuating, and falling. In terms of spatial changes, the area of alpine lakes in the Himalayan Mountains, the Karakoram Mountains, and the Qaidam Basin tended to decrease; the area of lakes in the Naqu region and the Kunlun Mountains increased; and the area of lakes in the Hoh Xil region and Qilian Mountains fluctuated. Changes in lake water level and area were correlated with regional changes in climate. Reasons for changes in these lakes on the Tibetan Plateau were analyzed, including precipitation and evaporation from meteorological data, glacier meltwater from the Chinese glacier inventories. Several key problems, e.g. challenges of monitoring water balance, limitations to glacial area detection, uncertainties in detecting lake water-level variations and variable region boundaries of lake change types on the Tibetan Plateau were discussed. This research has most indicative significance to regional climate change.